What is the dose of anti-D immune globulin administered to Rh-negative women after a first-trimester miscarriage?

The correct dose of anti-D immune globulin for Rh-negative women after a first-trimester miscarriage is 50 mcg. This particular dosage is specifically recommended to prevent Rh sensitization in the event of fetal Rh-positive blood mixing with the maternal circulation.

Administering 50 mcg is considered sufficient for a first-trimester event, as the risk of Rh immunization from a miscarriage at this stage is lower compared to later gestations. Higher doses, such as 150 mcg or 200 mcg, may be reserved for different clinical scenarios, such as after a second-trimester miscarriage or procedures that have a higher likelihood of blood mixing.

Therefore, the 50 mcg dose is tailored to the specific risk associated with first-trimester losses while addressing the need to effectively mitigate the possibility of sensitization in Rh-negative women.